Publications from the Kavran Lab

Tran T, Mitra J, Ha T, Kavran JM. Increasing kinase domain proximity promotes MST2 autophosphorylation during Hippo signaling (2020) J. Biol. Chem. 295(47):16166-16179.

Cairns L, Patterson A, Weingartner KA, Koehler TJ, DeAngelis DR, Tripp KW, Bothner B, Kavran JM. Biophysical characterization of SARAH domain-mediated multimerization of Hippo pathway complexes in Drosophila. (2020) J Biol Chem. 295(18):6202-6213.

Cairns L, Tran T, Fowl BH, Patterson A, Kim YJ, Bothner B, Kavran JM. Salvador has an extended SARAH domain that mediates binding to Hippo kinase. (2018) J Biol Chem. 293(15):5532-5543.

Ingavat N, Kavran JM, Sun Z, Rokita SE. Active Site Binding Is Not Sufficient for Reductive Deiodination by Iodotyrosine Deiodinase. (2017) Biochemistry. 56(8):1130-1139.

Cairns L, Tran T, Kavran JMStructural insights into the regulation of Hippo signaling.  (2017) ACS Chem. Biol. 12:601-610.

Publications as a Post-doctoral Fellow

Marold, JD, Kavran, JM, and Barrick, D.   A naturally occurring repeat protein with high internal sequence identity defines a new class of TPR-like proteins.  Structure.   In press

Werner, R, Merz, H, Strom, T, Birnbaum, W, Marshall, L, Schroder, T, Reiz, B, Kavran, JM, and Hior, O.  (2015) Unusual 46,XY Gonadal Dysgenesis due to a homozygous mutation in Desert Hedgehog (DHh) identified by exome-sequencing.  J. Clin. Endocrin. Metab.  100: 1022-1029.

Guo, LT, Wang, YS, Nakamura, A, Eiler, D, Kavran, JM, Wong, M, Kiessling, LL, Steitz, TA, O’Donoghue, P, Soll, D.   Polyspecific pyrrolysyl-tRNA synthetases from directed evolution.  (2014) Proc. Natl. Acad. Sci.  111, 16724-16729.

Wang, Y, Kavran, JM, Chen, Z, Karukurichi, K, Leahy, DJ, and Cole,  PA.  (2014) Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation.  J. Biol. Chem.  289, 31361-31372.

Kavran, JM, McCabe, JM, Byrne, PO, Connacher, MK, Wang, Z, Ramek, A, Sarabipour, S, Shan, Y, Hristova, K, Shaw, DE, Cole, PA, and Leahy, DJ.    How IGF-1 activates its receptor. (2014)  Elife. 3:e03772.

Commentary: Hubbard, SR and Miller, WT.  Receptor Signaling: Closing in on a mechanism for activation.  (2014) Elife.  3:e04909.

Kavran, JM, Ward, MD, Oladosu, OO, Mulepati, S and Leahy, DJ.  (2010) All mammalian Hedgehog proteins interact with cell adhesion molecule, down regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.  J. Biol. Chem.  283, 24584-90.

Qiu, C, Tarrant, MK, Boronina, T, Longo, PA, Kavran, JM, Cole, RN, Cole, PA, and Leahy, DJ.  (2009)  In vitro enzymatic characterization of near full length EGFR in activated and inhibited states.  Biochemistry.  48,  6624-32.