We investigate the molecular mechanisms of signaling pathways using a combination of structural biology, biochemistry, and cell-based assays. This allows us to understand how a pathway is regulated, how small molecules can influence a pathway, or how mutations to pathway components can alter its activity.  

In plain English this means we want to know how cells receive information from their environment and then how they know to respond accordingly.   We achieve this by looking at the three-dimensional shape of all the components, how these components fit together, and how these components or molecular machines do work.

We are part of the Department of Biochemistry & Molecular Biology in the Bloomberg School of Public Health of Johns Hopkins University.