Publications from the Kavran Lab

Cairns L, Tran T, Kavran JM.  Structural insights into the regulation of Hippo signaling.  (2017) ACS Chem. Biol. 12:601-610.

Publications as a Post-doctoral Fellow

Marold, JD, Kavran, JM, and Barrick, D.   A naturally occurring repeat protein with high internal sequence identity defines a new class of TPR-like proteins.  Structure.   In press

Werner, R, Merz, H, Strom, T, Birnbaum, W, Marshall, L, Schroder, T, Reiz, B, Kavran, JM, and Hior, O.  (2015) Unusual 46,XY Gonadal Dysgenesis due to a homozygous mutation in Desert Hedgehog (DHh) identified by exome-sequencing.  J. Clin. Endocrin. Metab.  100: 1022-1029.

Guo, LT, Wang, YS, Nakamura, A, Eiler, D, Kavran, JM, Wong, M, Kiessling, LL, Steitz, TA, O’Donoghue, P, Soll, D.   Polyspecific pyrrolysyl-tRNA synthetases from directed evolution.  (2014) Proc. Natl. Acad. Sci.  111, 16724-16729.

Wang, Y, Kavran, JM, Chen, Z, Karukurichi, K, Leahy, DJ, and Cole,  PA.  (2014) Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation.  J. Biol. Chem.  289, 31361-31372.

Kavran, JM, McCabe, JM, Byrne, PO, Connacher, MK, Wang, Z, Ramek, A, Sarabipour, S, Shan, Y, Hristova, K, Shaw, DE, Cole, PA, and Leahy, DJ.    How IGF-1 activates its receptor. (2014)  Elife. 3:e03772.

Commentary: Hubbard, SR and Miller, WT.  Receptor Signaling: Closing in on a mechanism for activation.  (2014) Elife.  3:e04909.

Kavran, JM, Ward, MD, Oladosu, OO, Mulepati, S and Leahy, DJ.  (2010) All mammalian Hedgehog proteins interact with cell adhesion molecule, down regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.  J. Biol. Chem.  283, 24584-90.

Qiu, C, Tarrant, MK, Boronina, T, Longo, PA, Kavran, JM, Cole, RN, Cole, PA, and Leahy, DJ.  (2009)  In vitro enzymatic characterization of near full length EGFR in activated and inhibited states.  Biochemistry.  48,  6624-32.